Open AccessNeurobehavioural Changes in a Hemiparkinsonian Rat Model Induced by Rotenone
Author(s) -
Sukala Puthuparambil Maniyath
Publication year - 2017
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2017/24955.9604
Subject(s) - rotenone , striatum , parkinson's disease , dopaminergic , neurotoxin , lesion , levodopa , medicine , toxicity , histology , pharmacology , dopamine , endocrinology , chemistry , pathology , disease , mitochondrion , biochemistry
Rotenone, a mitochondrial complex I inhibitor is used as a neurotoxin agent to reproduce the neuropathological, and behavioural feature of Parkinson's Disease (PD) in rat. Due to acute and chronic exposure of rotenone with various doses through different routes of administration, mortality is being reported. Low dose takes a longer duration to produce PD symptoms in animals. This present study was designed to create hemiparkinsonian 'partial' lesion model by rotenone at a single moderate dose in two sites of striatum in albino rats and also to assess its toxicity by behavioural parameters and by microscopic study.