Open AccessPrimary Cutaneous Amyloidosis: A Clinical, Histopathological and Immunofluorescence Study
Author(s) -
Krati Mehrotra,
Rupali Dewan,
Jitendra Kumar,
Abhinav Dewan
Publication year - 2017
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2017/24273.10334
Subject(s) - histopathology , pathology , amyloidosis , medicine , stain , haematoxylin , immunofluorescence , amyloid (mycology) , eosinophilic , papillary dermis , hyaline , staining , dermis , antibody , immunology
Primary Localized Cutaneous Amyloidosis (PLCA) is a relatively rare chronic condition characterized by amyloid deposition in dermis without associated deposits in internal organs. Histopathology of cutaneous amyloidosis using Haematoxylin and Eosin (H&E) stain shows eosinophilic hyaline material in papillary dermis, which can be further confirmed by Congo Red (CR) staining or Direct Immunofluorescence (DIF) Test or immunohistochemistry.