Open AccessCorrelation of Plasma Neutrophil Elastase Activity and Endogenous Protease Inhibitor Levels with the Severity of Pre-eclampsia
Author(s) -
Mamatha Kunder,
AV Moideen Kutty,
V Lakshmaiah,
S R Sheela
Publication year - 2017
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2017/24181.9469
Subject(s) - medicine , elastase , endocrinology , endogeny , pathophysiology , neutrophil elastase , uric acid , chemistry , enzyme , inflammation , biochemistry
Pre-eclampsia (PE) is a common maternal syndrome characterized by severe systemic inflammatory response including neutrophil activation leading to uncontrolled activity of elastase. The excessive activity of elastase would lead to destroyal of the integrity of endothelial cells and could exacerbate the pathophysiological symptoms in PE. Thus, assessment of NE activity and its control mechanisms would be of relevance in the determination of severity of PE.