Open AccessEmergence of Carbapenem Resistant Non-Fermenting Gram-Negative Bacilli Isolated in an ICu of a Tertiary Care Hospital
Author(s) -
Sonika Agarwal,
Barnali Kakati,
Sushant Khanduri,
Shalini Gupta
Publication year - 2017
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2017/24023.9317
Subject(s) - stenotrophomonas maltophilia , acinetobacter baumannii , microbiology and biotechnology , acinetobacter , pseudomonas aeruginosa , bacilli , drug resistance , medicine , antibiotics , carbapenem , biology , bacteria , genetics
The emergence and spread of Multi-Drug Resistant (MDR) Non-Fermenting Gram-Negative Bacilli (NFGNB) in Intensive Care Units (ICU) and their genetic potential to transmit diverse antibiotic resistance regardless of their ability to ferment glucose poses a major threat in hospitals. The complex interplay of clonal spread, persistence, transmission of resistance elements and cell-cell interaction leads to the difficulty in controlling infections caused by these multi drug-resistant strains. Among non-fermenting Gram-negative rods, the most clinically significant species Pseudomonas aeruginosa , Acinetobacter baumannii and Stenotrophomonas maltophilia are increasingly acquiring resistant to carbapenems. Carbapenems once considered as a backbone of treatment of life threatening infections appears to be broken as the resistance to carbapenems is on rise.