Open AccessStudy of Dickkopf-1 (DKK-1) Gene Expression in Hepatocellular Carcinoma Patients
Author(s) -
Mona Watany
Publication year - 2017
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2017/23095.9450
Subject(s) - hepatocellular carcinoma , medicine , serology , antibody , carcinogenesis , wnt signaling pathway , biomarker , cancer , hepatitis c virus , gene , gastroenterology , oncology , immunology , virus , biology , biochemistry
Hepatocellular Carcinoma (HCC) is the sixth most common cancer in the world. Dickkopf -1 (DKK-1) protein is a new biomarker used in conjunction with Alpha Fetoprotein (AFP) to differentiate HCC from "non-malignant" liver disease. DKK-1 is an inhibitor of Wnt/β-catenin signaling pathway which is involved in embryogenesis and has been implicated in tumorigenesis in many tissues.