Study of Dickkopf-1 (DKK-1) Gene Expression in Hepatocellular Carcinoma Patients | Zendy

Mona M. Watany | Zendy; Rehab Badawi | Zendy; Walaa Elkhalawany | Zendy; Sherief AbdElsalam | Zendy

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Study of Dickkopf-1 (DKK-1) Gene Expression in Hepatocellular Carcinoma Patients

Author(s) -

Mona M. Watany,

Rehab Badawi,

Walaa Elkhalawany,

Sherief AbdElsalam

Publication year - 2017

Publication title -

journal of clinical and diagnostic research

Language(s) - English

Resource type - Journals

eISSN - 2249-782X

pISSN - 0973-709X

DOI - 10.7860/jcdr/2017/23095.9450

Subject(s) - hepatocellular carcinoma , medicine , serology , antibody , carcinogenesis , wnt signaling pathway , biomarker , hepatitis c virus , cancer , gene , gastroenterology , oncology , immunology , virus , biology , biochemistry

Hepatocellular Carcinoma (HCC) is the sixth most common cancer in the world. Dickkopf -1 (DKK-1) protein is a new biomarker used in conjunction with Alpha Fetoprotein (AFP) to differentiate HCC from "non-malignant" liver disease. DKK-1 is an inhibitor of Wnt/β-catenin signaling pathway which is involved in embryogenesis and has been implicated in tumorigenesis in many tissues.

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