Open AccessCyclophosphamide and Doxorubicin Induced Melanonychia: A Case Report
Author(s) -
Vivek Bhanubhai Prajapati,
Sampath Madhyastha,
Raviraja V Acharya,
Vinaya Gopalaswamy,
Akhila Doddamani
Publication year - 2017
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2017/23041.9216
Subject(s) - medicine , hyperpigmentation , dermatology , cyclophosphamide , vincristine , doxorubicin , prednisone , rituximab , chop , lymphoma , chemotherapy
Chemotherapeutic agents may rarely cause discoloration and hyperpigmentation of the nails. We present a patient who developed blackish discoloration of nails also referred as melanonychia during six cycles of R-CHOP chemotherapy regimen (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone) for the treatment of Non Hodgkin Lymphoma (NHL) follicular type. The patient developed blackish brown discoloration in all the nails. As suggested by previous literature evidence the melanonychia could be associated with cyclophosphamide and doxorubicin. According to the Naranjo causality assessment scale, we established that there was a 'probable' association of nail discoloration with the drug.