Open AccessAnti-C1q Antibody is Associated with Renal and Cutaneous Manifestations in Asian Indian Patients with Systemic Lupus Erythematosus
Author(s) -
Jayakanthan Kabeerdoss,
Nikhil Gupta,
Pulukool Sandhya,
Hindhumathi Mohan,
Gowri Mahasampath,
Debashish Danda
Publication year - 2017
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2017/22661.9545
Subject(s) - medicine , rheumatology , lupus nephritis , serology , antibody , renal biopsy , immunology , mucocutaneous zone , systemic lupus erythematosus , anti nuclear antibody , gastroenterology , renal function , autoantibody , disease
C1q play an important role in clearance of immune complexes and apoptotic cell debris. Impaired clearance leads to exposure of C1 native antigen and development of anti-C1q antibody formation. Anti-C1q antibody is well studied in Systemic Lupus Erythematosus (SLE). Significance of anti-C1q Ab in Indian SLE patients and their clinical manifestations is not clear.