Anti-C1q Antibody is Associated with Renal and Cutaneous Manifestations in Asian Indian Patients with Systemic Lupus Erythematosus | Zendy

Jayakanthan Kabeerdoss | Zendy; Nikhil Gupta | Zendy; Pulukool Sandhya | Zendy; H Mohan | Zendy; Gowri Mahasampath | Zendy; Debashish Danda | Zendy

Open Access

Anti-C1q Antibody is Associated with Renal and Cutaneous Manifestations in Asian Indian Patients with Systemic Lupus Erythematosus

Author(s) -

Jayakanthan Kabeerdoss,

Nikhil Gupta,

Pulukool Sandhya,

H Mohan,

Gowri Mahasampath,

Debashish Danda

Publication year - 2017

Publication title -

journal of clinical and diagnostic research

Language(s) - English

Resource type - Journals

eISSN - 2249-782X

pISSN - 0973-709X

DOI - 10.7860/jcdr/2017/22661.9545

Subject(s) - medicine , rheumatology , lupus nephritis , serology , antibody , renal biopsy , immunology , mucocutaneous zone , systemic lupus erythematosus , anti nuclear antibody , gastroenterology , renal function , autoantibody , disease

C1q play an important role in clearance of immune complexes and apoptotic cell debris. Impaired clearance leads to exposure of C1 native antigen and development of anti-C1q antibody formation. Anti-C1q antibody is well studied in Systemic Lupus Erythematosus (SLE). Significance of anti-C1q Ab in Indian SLE patients and their clinical manifestations is not clear.

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