Open AccessAssociation between Single Nucleotide Polymorphisms of SMAD3 and BMP5 with the Risk of Knee Osteoarthritis
Author(s) -
Ashish Sharma,
Rajeshwar Nath Srivastava,
S.R. Srivastava,
Devendra Parmar,
Ajai Singh,
Saloni Raj
Publication year - 2017
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2017/22371.10073
Subject(s) - single nucleotide polymorphism , osteoarthritis , medicine , genotype , logistic regression , oncology , genetics , biology , gene , pathology , alternative medicine
The role of genetic factors influencing osteoarthritis (OA) susceptibility is well documented and several candidate genes have been identified to be associated with it. Among these genes are Bone Morphogenetic Protein 5 ( BMP5 ) and Smad family member 3 ( SMAD3) , all involved in Transforming Growth Factor (TGF) signaling pathway. The knee is the commonly affected joint, and knee OA has an especially high prevalence in Asian population.