Association between Single Nucleotide Polymorphisms of SMAD3 and BMP5 with the Risk of Knee Osteoarthritis | Zendy

Amar Chandra Sharma | Zendy; Ruchi Srivastava | Zendy; Sudeepti Ratan Srivastava | Zendy; Devendra Parmar | Zendy; Ajai Singh | Zendy; Saloni Raj | Zendy

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Association between Single Nucleotide Polymorphisms of SMAD3 and BMP5 with the Risk of Knee Osteoarthritis

Author(s) -

Amar Chandra Sharma,

Ruchi Srivastava,

Sudeepti Ratan Srivastava,

Devendra Parmar,

Ajai Singh,

Saloni Raj

Publication year - 2017

Publication title -

journal of clinical and diagnostic research

Language(s) - English

Resource type - Journals

eISSN - 2249-782X

pISSN - 0973-709X

DOI - 10.7860/jcdr/2017/22371.10073

Subject(s) - single nucleotide polymorphism , osteoarthritis , genotype , medicine , logistic regression , oncology , genetics , gene , biology , pathology , alternative medicine

The role of genetic factors influencing osteoarthritis (OA) susceptibility is well documented and several candidate genes have been identified to be associated with it. Among these genes are Bone Morphogenetic Protein 5 ( BMP5 ) and Smad family member 3 ( SMAD3) , all involved in Transforming Growth Factor (TGF) signaling pathway. The knee is the commonly affected joint, and knee OA has an especially high prevalence in Asian population.

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