Open AccessIncreased Advanced Oxidation Protein Products Generation by Cyclosporine-A and Angiotensin II in Human Gingival Fibroblasts – Ex-vivo Study
Author(s) -
Suresh Ranga Rao,
Subbiah Rajasekaran,
Supraja Ajitkumar,
Dinesh Murugan Girija
Publication year - 2017
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2017/22246.9183
Subject(s) - oxidative stress , ex vivo , angiotensin ii , chemistry , fibrosis , pharmacology , in vivo , renin–angiotensin system , endocrinology , in vitro , medicine , biochemistry , receptor , biology , microbiology and biotechnology , blood pressure
Cyclosporin-A (CsA), an immunosuppressant, induces renal fibrosis and Renin Angiotensin System (RAS) is known to play a major role. CsA has the potential to increase the oxidative stress; specifically through the Advanced Oxidation Protein Products (AOPP) which could possibly stimulate fibrosis. A similar type of pathology occurs even in the gingiva known as CsA Induced Gingival Overgrowth (CIGO).