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Evaluation of CYP1B1 Expression, Oxidative Stress and Phase 2 Detoxification Enzyme Status in Oral Squamous Cell Carcinoma Patients
Author(s) -
Shailza Verma,
Rahul Saxena,
Merajul Haque Siddiqui,
K Santha,
S Sethupathy
Publication year - 2017
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2017/22196.9324
Subject(s) - oxidative stress , cyp1b1 , carcinogenesis , malondialdehyde , antioxidant , carcinogen , medicine , glutathione , cancer , biomarker , enzyme , biology , physiology , cancer research , biochemistry , metabolism , cytochrome p450
Oral Squamous Cell Carcinoma (OSCC) affects global health with increasing incidence and mortality rate. It may involve exposure to carcinogens from tobacco smoking or chewing. Alteration in expression of gene encoding the enzymes concerned with carcinogen biotransformation along with oxidative stress may increase or decrease the risk of cancer.

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