Open AccessEvaluation of Cyclin D1 expression in Head and Neck Squamous Cell Carcinoma
Author(s) -
Dhingra,
Jyoti Verma,
Satya Ranjan Misra,
Sudesh Srivastav,
Faheema Hasan
Publication year - 2017
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2017/21760.9329
Subject(s) - cyclin d1 , medicine , stage (stratigraphy) , oncology , lymph node , malignancy , immunohistochemistry , head and neck squamous cell carcinoma , pathology , head and neck cancer , cancer , cell cycle , biology , paleontology
Squamous Cell Carcinoma (SCC) is an aggressive epithelial malignancy of the upper aero digestive tract and comprises 90% of all Head and Neck Squamous Cell Carcinoma (HNSCC). It is the sixth leading cancer worldwide with approximately 600,000 cases reported annually. It is one of the most common cancers in India. Tumour Lymph Node and Metastases (TNM) staging has been the most useful indicator to predict prognosis in HNSCC but recently various biomolecular markers have potentially offered new methods for early diagnosis and treatment alternatives for HNSCC patients; one amongst them being cyclin D1.