Open AccessCan Salivary Acetylcholinesterase be a Diagnostic Biomarker for Alzheimer?
Author(s) -
Somayeh Bakhtiari,
Nahid Beladi Moghadam,
Marjan Ehsani,
Hamed Mortazavi,
Siamak Sabour,
Mahin Bakhshi
Publication year - 2017
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2017/21715.9192
Subject(s) - acetylcholinesterase , saliva , aché , cholinergic , biomarker , medicine , endocrinology , alzheimer's disease , cholinesterase , mann–whitney u test , disease , physiology , chemistry , enzyme , biochemistry
The loss of brain cholinergic activity is a key phenomenon in the biochemistry of Alzheimer's Disease (AD). Due to the specific biosynthesis of Acetylcholinesterase (AChE) of cholinergic neurons, the enzyme has been proposed as a potential biochemical marker of cholinergic activity. AChE is expressed not only in the Central Nervous System (CNS), Peripheral Nervous System (PNS) and muscles, but also on the surface of blood cells and saliva.