Open AccessA Comparison of 2-Methoxyestradiol Value in Women with Severe Preeclampsia Versus Normotensive Pregnancy
Author(s) -
John Wantania,
Ahsanuddin Attamimi,
Rukmono Siswishanto
Publication year - 2017
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2017/21516.9603
Subject(s) - preeclampsia , pregnancy , medicine , obstetrics , proteinuria , endothelial dysfunction , gestational hypertension , vascular endothelial growth factor , gestational age , endocrinology , gynecology , vegf receptors , biology , genetics , kidney
Preeclampsia is a pregnancy complication characterized by high blood pressure and proteinuria. Endothelial dysfunction is a major theory suggested as its aetiology. It is caused by anti-angiogenic condition characterized by low Vascular Endothelial Growth Factor (VEGF). An estradiol metabolite, called 2-Methoxy Estradiol (2-ME), is produced with the help of Catechol-O-Methyltransferase (COMT). This substance has an important role in VEGF expression. A 2-ME is suppressed in women with preeclampsia.