Open AccessAssociation of C-Reactive Protein (rs1205) Gene Polymorphism with Susceptibility to Psoriasis in South Indian Tamils
Author(s) -
Anjana Sudhesan,
Medha Rajappa,
Laxmisha Chandrashekar,
Palghat Hariharan Ananthanarayanan,
Devinder Mohan Thappa,
Santhosh Satheesh,
Adithan Chandrasekaran,
Panneer Devaraju
Publication year - 2016
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2016/23391.8624
Subject(s) - psoriasis , single nucleotide polymorphism , c reactive protein , medicine , snp , genotype , psoriasis area and severity index , immunology , allele , gastroenterology , biology , inflammation , genetics , gene
Psoriasis is a multi-factorial heritable T-helper Th-1/Th-17 mediated inflammatory disease, affecting the skin. It is associated with co-morbidities such as Cardiovascular Disease (CVD). C-Reactive Protein (CRP) is a good inflammatory marker. CRP rs1205 polymorphism is associated with circulating plasma CRP levels. Although there is association between the rs1205 Single Nucleotide Polymorphism (SNP) and CVD, there are no prior reports regarding the association of CRP rs1205 SNP with psoriasis susceptibility.