Open AccessRole of Altered Venous Blood Lactate and H b A 1C in Women with Gestational Diabetes Mellitus
Author(s) -
CS Nagalakshmi
Publication year - 2016
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2016/23342.9095
Subject(s) - gestational diabetes , medicine , hyperinsulinemia , obstetrics , fetus , cord blood , umbilical cord , pregnancy , diabetes mellitus , gestational age , gestation , venous blood , endocrinology , oxygen saturation , prospective cohort study , umbilical vein , insulin resistance , biology , oxygen , chemistry , biochemistry , genetics , organic chemistry , anatomy , in vitro
Being a mirror image of metabolic syndrome, Gestational Diabetes Mellitus (GDM) is associated with significant maternal and fetal morbidity. Increased blood lactate concentration and alterations of substrate utilization are partly involved in development of insulin resistance in GDM. Fetuses born to such mothers have shown low umbilical vein oxygen saturation and low oxygen content and increased lactate concentrations. These changes may certainly reflect enhanced fetal metabolism as a result of hyperglycaemia and hyperinsulinemia and therefore, these fetuses deserve intense surveillance at term and during delivery. Ideally, HbA1c should be maintained below 5% during their first trimesters and below 6% during third trimester. We planned to investigate GDM women for their HbA1c levels too.