Open AccessAmyloidosis: The Newer Discovered ALECT2 Associated with der7q add(7)
Author(s) -
Amrita Chakrabarti,
Priyanka Samal,
Joydeep Chakrabartty
Publication year - 2016
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2016/21705.8555
Subject(s) - amyloidosis , pathological , amyloid (mycology) , pathology , proteinuria , abnormality , bone marrow , medicine , kidney , psychiatry
Amyloidosis is characterized by pathological deposition of abnormal protein aggregates in various tissues, AL protein being the commonest. ALECT 2 is the newest protein described, having a predisposition to affect the kidneys, sometimes the liver and rarely other organs. We present a case of renal amyloid ALECT 2 due to leucocyte cell derived chemotaxin 2, a novel amyloidogenic protein. The patient presented with mild proteinuria, scattered plasma cells on bone marrow examination and altered kappa/lambda ratio with associated cytogenetic abnormality of der7q add(7). It is essential to correctly type this protein and differentiate it from AL during diagnosis for appropriate and effective clinical management.