Open AccessOfloxacin Induced Angioedema: A Rare Adverse Drug Reaction
Author(s) -
Gautam Rawal,
Sankalp Yadav,
Rajiv Kumar,
Umar Rasool Wani
Publication year - 2016
Publication title -
journal of clinical and diagnostic research
Language(s) - Uncategorized
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2016/21316.8782
Subject(s) - angioedema , ofloxacin , medicine , pharmacovigilance , adverse drug reaction , dermatology , drug , intensive care medicine , hypersensitivity reaction , incidence (geometry) , rare disease , ingestion , antibiotics , drug reaction , adverse effect , pediatrics , disease , pharmacology , ciprofloxacin , physics , optics , microbiology and biotechnology , biology
The Adverse Drug Reaction (ADR) to a commonly prescribed anti-microbial can pose a major public health problem. The authors report a rare case of 24-year-old young lady who presented with angioedema of lips after ingestion of Ofloxacin, prescribed to her for treatment of loose motions. Fluoroquinolones are widely prescribed antibiotics for various disease conditions. The history, clinical examination and normal laboratory parameters led to the diagnosis of ofloxacin induced hypersensitivity reaction and the patient was successfully treated with corticosteroids and antihistamines. The hypersensitivity reactions to fluoroquinolones are rare with an incidence of 0.4% to 2%. The pharmacovigilance program and self-reporting of all the ADR's by the health care workers can help in ensuring the judicious use of the drug, drug safety and thus decrease the associated morbidity and mortality.