Open AccessDoes 24bp Duplication of Human CHIT1 Gene (Chitotriosidase1) Predispose to Filarial Chyluria? A Case-Control Study
Author(s) -
Shriya Pant,
Jyotsna Agarwal,
Apul Goel,
Pravin Kumar Gangwar,
Mohammad Waseem,
Prashant Gupta,
Satya Narayan Sankhwar,
Bimalesh Purkait
Publication year - 2016
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2016/20987.8423
Subject(s) - chyluria , gene duplication , wuchereria bancrofti , lymphatic filariasis , biology , immunology , population , filariasis , lymphatic system , medicine , gene , genetics , helminths , environmental health
Chyluria which is endemic in many parts of the world is mainly caused by Wuchereria bancrofti. CHIT1 (chitotriosidase) is produced by macrophages and plays an important role in the defense against chitin containing pathogen such as filarial parasite. Variation in the coding region with 24 bp duplication allele results in reduced CHIT1 activity that enhance the survival of parasite which may play a role in the occurrence of disease.