Open AccessA Case of Macrophage Activation Syndrome with Acute Respiratory Distress Syndrome
Author(s) -
Robin George Manappallil
Publication year - 2016
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2016/20902.8518
Subject(s) - macrophage activation syndrome , ards , medicine , acute respiratory distress , immunology , respiratory distress , macrophage , rheumatoid arthritis , respiratory system , arthritis , lung , biology , surgery , biochemistry , in vitro
Macrophage Activation Syndrome (MAS) is a rare form of Haemophagocytic Lymphohistiocytosis (HLH) associated with rheumatologic conditions. It is characterised by haemophagocytosis and cytokine overproduction, resulting from the activation and uncontrolled proliferation of T lymphocytes and macrophages. The patient being reported is an elderly female with Rheumatoid Arthritis (RA), who presented with fever and was found to have MAS. She later developed Acute Respiratory Distress Syndrome (ARDS) and died. Such a scenario has rarely been reported.