Open AccessCongenital Acute Myeloid Leukaemia with Pseudo-Chediak-Higashi Like Granules: A Case Report
Author(s) -
Vandana Puri,
Sandip Barman,
Pooja Sharma,
Meera Sikka
Publication year - 2016
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2016/20740.8926
Subject(s) - myeloid leukaemia , medicine , myeloid , differential diagnosis , pathology , chédiak–higashi syndrome , chronic myeloid leukaemia , immunology
Congenital leukaemia is a very rare entity comprising 0.8% of all childhood leukaemias. Pseudo-Chediak-Higashi Anomaly (PCHA) in acute leukaemia is a rarely described entity. However, co-existence of congenital myeloid leukaemia with PCHA is a very rare entity and to the best of our knowledge has not been described in literature till date. A full term new-born presented on the 27 th day of life with severe gastroenteritis. Complete blood counts and peripheral smear examination revealed leucocytosis with presence of 76% blast cells. Approximately 15% of these blast cells showed presence of pseudo-Chediak-Higashi like granules. The diagnosis of acute myeloid leukaemia was confirmed by flow cytometry. The case report is presented due to its rarity and to highlight the differential diagnosis and clinical implications of this entity.