Open AccessRisk Stratification in Paragangliomas with PASS (Pheochromocytoma of the Adrenal Gland Scaled Score) and Immunohistochemical Markers
Author(s) -
M. L. Kulkarni,
Siddhi Gaurish Sinai Khandeparkar,
Sanjay D Deshmukh,
Rajesh Karekar,
Vandana L. Gaopande,
Avinash R Joshi,
Mrunal Kesari,
Rahul Ramkrishna Shelke
Publication year - 2016
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2016/20565.8419
Subject(s) - paraganglioma , pheochromocytoma , medicine , malignancy , chromogranin a , synaptophysin , immunohistochemistry , histopathology , pathology , adrenal gland
Paragangliomas (PGLs) are rare tumours that arise in sympathetic and parasympathetic paraganglia and are derived from neural crest cells. Presence of metastasis is the only absolute criterion for malignancy. There is no single histo-morphological feature indicating malignant potential and multiple parameters have been proposed to prognosticate the individual case. This includes studies conducted using Pheochromocytoma of the Adrenal Gland Scaled Score (PASS) and Immunohistochemical (IHC) markers.