Open AccessHIF-1 a and GLUT-1 Expression in Atypical Endometrial Hyperplasia, Type I and II Endometrial Carcinoma: A Potential Role in Pathogenesis
Author(s) -
Dalia Rifaat Al-Sharaky,
Asmaa Gaber Abdou,
Moshira Mohammed Abdel Wahed,
Hend A. Abdo Kassem
Publication year - 2016
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2016/19576.7805
Subject(s) - immunohistochemistry , carcinoma , stromal cell , medicine , glucose transporter , endometrial cancer , pathogenesis , hyperplasia , pathology , atypical hyperplasia , oncology , cancer , insulin
Hypoxia-Inducible Factor 1α (HIF-1α) is one of the major adaptive responses to hypoxia, regulating the activity of glucose transporter -1 (GLUT-1), responsible for glucose uptake.