Open AccessEffects of Diaceto-Dipropyl-Disulphide on Plasma Sialic Acid and Renal Tissue Thiol Levels in Alloxan Diabetic Rats
Author(s) -
Venkataiah,
Vickram,
Thirumalarao Kr,
Raiker Vg,
Puttaswamy Sh
Publication year - 2016
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2016/19241.8058
Subject(s) - alloxan , endocrinology , medicine , chemistry , diabetic nephropathy , thiol , sialic acid , diabetes mellitus , kidney , intraperitoneal injection , antioxidant , tbars , biochemistry , lipid peroxidation
Plasma sialic acid levels are elevated in Diabetes Mellitus (DM) patients with proteinuria. Renal damage is mainly caused by free radicals that are excessively generated in DM. Thiols play an important role in the cellular antioxidative defence mechanisms mainly through thiol-disulphide exchange reaction. Diallyl disulphide, a garlic oil principle component, is known for its anti-diabetic properties. Its structural analogue, Diaceto-Dipropyl Disulphide (DADPDS), is a less toxic and more palatable disulphide and possesses similar anti-diabetic actions.