Open AccessGalactomannan Assay and Invasive Pulmonary Aspergillosis - Comparison of the Test Performance at an in-house and the Kit Cut-off
Author(s) -
Jayanthi Savio,
Nikhilesh Ravikumar Me,
Arun Ramachandran Sudharma,
Vinutha Jairaj,
Joshila Mathew
Publication year - 2016
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2016/19175.8310
Subject(s) - galactomannan , medicine , receiver operating characteristic , aspergillosis , cut off , predictive value , population , area under the curve , surgery , gastroenterology , immunology , power (physics) , physics , environmental health , quantum mechanics
Invasive Pulmonary Aspergillosis (IPA) is an important opportunistic infection with a high degree of mortality and morbidity. Galactomannan assay (GM assay) is found to be useful for diagnosis of IPA in patients with neutropenia. However the utility of this assay has not been evaluated in a mixed patient population with other co-morbid conditions. Though a kit cut-off of 0.5 has been recommended for the diagnosis of IPA, studies have reported a higher sensitivity with cut-offs more than 0.5.