Open AccessCan Feulgen Stain be a Reliable Biomarker over PAP Stain for Estimation of Micronuclei Score?
Author(s) -
Manish Kumar,
Umesh Chandra Prasad,
Betina Chandolia,
Sandesh Manjunath,
Shiva Basu,
Silvie Verma
Publication year - 2016
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2016/18859.8630
Subject(s) - feulgen stain , stain , chewing tobacco , micronucleus test , medicine , lesion , staining , pathology , tobacco smoke , malignant transformation , statistical significance , micronucleus , cancer , toxicity , environmental health
Malignant transformation of the Potentially Malignant Lesions (PML) in the oral cavity is associated with elevated mortality rate because of its aggressive and exceedingly invasive nature. Meticulous diagnosis and prompt therapy of PML may help prevent malignant conversion in oral lesions. Carcinogenic insult to oral cells results in chromosomal damage and formation of Micronuclei (Mn), before the development of clinical symptoms.