Open AccessAn Unusual Case of H CV Negative Cryoglobulinemia Presenting as Symmetrical Peripheral Gangrene
Author(s) -
Siba Prasad Dalai,
Lalit Kumar Meher,
Samir Kumar Behera,
Sachidananda Nayak,
Sujit Kumar Trıpathy
Publication year - 2016
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2016/18673.7625
Subject(s) - cryoglobulinemia , cryoglobulins , gangrene , medicine , vasculitis , thrombosis , pathology , peripheral , immunology , monoclonal , gastroenterology , dermatology , antibody , monoclonal antibody , hepatitis c virus , virus , disease
Cryoglobulins are monoclonal or polyclonal immunoglobulins that undergo reversible precipitation at low temperatures. Cryoglobulinemia is associated with HCV infection in more than 90% cases, the remaining 10% being called as Essential Cryoglobulinemia which is generally associated with a severe course and suboptimal response to conventional therapies. As the digital vessels are more prone to colder temperatures, hyperviscosity in those vessels can initiate local thrombosis and may manifest as ischemic ulceration and gangrene. We report here a very unusual case of HCV negative cryoglobulinemic vasculitis presenting as symmetrical peripheral gangrene of fingers and toes.