Open AccessMalignant Peripheral Nerve Sheath Tumor -A Rare Malignancy in Mandible
Author(s) -
Swapan Majumdar
Publication year - 2016
Publication title -
journal of clinical and diagnostic research
Language(s) - Uncategorized
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2016/18263.8010
Subject(s) - malignant peripheral nerve sheath tumor , medicine , nerve sheath neoplasm , enolase , mandible (arthropod mouthpart) , trunk , neurofibroma , pathology , head and neck , lesion , malignancy , anatomy , neurofibromatosis , immunohistochemistry , surgery , biology , ecology , botany , genus
Malignant Peripheral Nerve Sheath Tumor (MPNST) is biologically an aggressive tumor that is usually found in the extremities, trunk and infrequently found in the head and neck area particularly in the jaws, arising from the cells allied with nerve sheath. Mandibular MPNST may either arise from a preexisting neurofibroma or develop de novo. Because of the greater variability from case to case in overall appearance both clinically and histologically, a case of MPNST of the mandible in a 25-year-old female patient is reported. The lesion was excised and immunohistological studies (S-100 & Neuron specific enolase) were conducted to confirm the neural origin.