Open AccessCisplatin Concentrations in Long and Short Duration Infusion: Implications for the Optimal Time of Radiation Delivery
Author(s) -
Pradeep Rajkumar,
Binu Mathew,
Das S,
Rajesh Isaiah,
Sheila John,
Ratna Prabha,
DH Fleming
Publication year - 2016
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2016/18181.8126
Subject(s) - cisplatin , medicine , radiation therapy , pharmacokinetics , anesthesia , chemotherapy , sensitization , urology , intravenous infusions , pharmacology , immunology
Cisplatin has radiosensitizing properties and the best sensitization to radiotherapy occurs with a higher plasma concentration of cisplatin. To our knowledge the optimal time sequence between chemotherapy and administration of radiation therapy, to obtain maximum effect from concurrent chemoradiation is unclear.