Cisplatin Concentrations in Long and Short Duration Infusion: Implications for the Optimal Time of Radiation Delivery | Zendy

Pradeep Rajkumar | Zendy; Binu Mathew | Zendy; Saikat Das | Zendy; Rajesh Isaiah | Zendy; Subashini John | Zendy; Ratna Prabha | Zendy; Denise H. Fleming | Zendy

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Cisplatin Concentrations in Long and Short Duration Infusion: Implications for the Optimal Time of Radiation Delivery

Author(s) -

Pradeep Rajkumar,

Binu Mathew,

Saikat Das,

Rajesh Isaiah,

Subashini John,

Ratna Prabha,

Denise H. Fleming

Publication year - 2016

Publication title -

journal of clinical and diagnostic research

Language(s) - English

Resource type - Journals

eISSN - 2249-782X

pISSN - 0973-709X

DOI - 10.7860/jcdr/2016/18181.8126

Subject(s) - cisplatin , medicine , radiation therapy , pharmacokinetics , anesthesia , chemotherapy , sensitization , intravenous infusions , continuous infusion , urology , pharmacology , immunology

Cisplatin has radiosensitizing properties and the best sensitization to radiotherapy occurs with a higher plasma concentration of cisplatin. To our knowledge the optimal time sequence between chemotherapy and administration of radiation therapy, to obtain maximum effect from concurrent chemoradiation is unclear.

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