Open AccessEvaluation of Protein Kinase C β and P PAR γ Activity in Diabetic Rats Supplemented with Momordica charantia
Author(s) -
Swetha Chandru,
Prashant Vishwanath,
Devananda Devegowda,
Suresha Nagaraja Ramasamudra,
Akila Prashant,
Basavanagowdappa Hathur
Publication year - 2016
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2016/18161.7653
Subject(s) - pioglitazone , medicine , momordica , endocrinology , thiazolidinedione , streptozotocin , lipid profile , diabetes mellitus , intraperitoneal injection , alloxan , insulin , potency , type 2 diabetes , chemistry , biochemistry , traditional medicine , in vitro
The present study was taken up to compare and evaluate the effect of Momordica charantia supplementation with pioglitazone on PKC-β and PPAR-γ activity in kidneys of diabetic rats. The hypoglycaemic and lipid lowering effect of Momordica charantia were screened in laboratory animal model and its potency was compared with a Thiazolidinedione (TZD) group antidiabetic drug like pioglitazone.