Open AccessCertainty of S100 from Physiology to Pathology
Author(s) -
Kuberappa Ph,
Bagalad Bs,
Anuradha Ananthaneni,
Kiresur Ma,
Srinivas Gv
Publication year - 2016
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2016/17949.8022
Subject(s) - s100 protein , biology , pathology , histogenesis , pathological , extracellular , microbiology and biotechnology , immunohistochemistry , medicine
S100 exists in wide variety of tissues and cell types, originally isolated from brain tissue and they are of low molecular weight proteins. S100 is evenly distributed in cytoplasm and also in nucleoplasm and is involved in both intercellular and extracellular functions. S100 protein is generally expressed in normal and also in pathological conditions. In current review, we discuss: a) update nomenclature of the various S100 proteins, b) expression of S100 in oral diseases (different soft tissue tumors, odontogenic cyst and tumor) for diagnostic value and also to know their histogenesis, c) role of S100 and RAGE receptor in oral squamous cell carcinoma.