Open AccessImmunohistochemical Detection of p75 Neurotrophin Receptor (p75-NTR) in Follicular and Plexiform Ameloblastoma
Author(s) -
Yoithapprabhunath Thukanayakanpalayam Ragunathan,
Nirmal Ramadas Madhavan,
Sunil Paramel Mohan,
Srichinthu Kenniyan Kumar
Publication year - 2016
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2016/17782.8280
Subject(s) - ameloblastoma , pathology , immunohistochemistry , biology , neurotrophin , receptor , medicine , anatomy , maxilla , biochemistry
Ameloblastoma holds a unique position among benign tumours by its locally destructive and invasive nature. Recently improvised molecular techniques helped researchers to unravel the myth behind such biologic behaviour. Though interesting findings have been delivered, the rhythmic correlation regarding the exact mechanism still remains lacking. Neurotrophins and their receptor mediated pathways play a crucial role in survival, death and differentiation of many neuroectoderm derived cells. With this background, the study has been aimed to investigate the expression of p75-NTR (Neurotrophin Receptor) in follicular and plexiform ameloblastoma.