Open AccessMetolazone Associated Stevens Johnson Syndrome-Toxic Epidermal Necrolysis Overlap
Author(s) -
Prabhat Kumar,
Abha Chauhan,
Riyaz Charaniya,
Anindya Ghosh,
Vaibhav Tandon
Publication year - 2016
Publication title -
journal of clinical and diagnostic research
Language(s) - Uncategorized
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2016/17768.7404
Subject(s) - toxic epidermal necrolysis , allopurinol , dermatology , medicine , mucocutaneous zone , antibiotics , sulfonamide , disease , microbiology and biotechnology , chemistry , biology , stereochemistry
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are severe mucocutaneous disease with high mortality rate. It is characterised by severe necrosis and detachment of the epidermis. Drugs are the most common triggering agent for SJS/TEN. These are commonly reported with the use of aromatic antiepileptics, antiretrovirals, allopurinol, NSAID'S and sulfonamide antibiotics. Non antibiotic sulfonamides rarely cause SJS/TEN. Metolazone is a well known diuretic and is extensively used by clinicians. Although this drug is in market for last several decades, no case of SJS/TEN has been reported till date. We report a rare case of metolazone induced SJS/TEN overlap in a 55-year-old lady.