Open AccessGyrA ser83 and ParC trp106 Mutations in Salmonella enterica Serovar Typhi Isolated from Typhoid Fever Patients in Tertiary Care Hospital
Author(s) -
Muthu Gopal,
Sathishkumar Elumalai,
A. Suresh,
Vishnuprabu Durairajpandian,
Munirajan Arasambattu Kannan,
Esthermary Selvam,
Seetharaman Srivani
Publication year - 2016
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2016/17677.8153
Subject(s) - typhoid fever , salmonella typhi , salmonella , microbiology and biotechnology , ciprofloxacin , dna gyrase , salmonella enterica , nalidixic acid , ofloxacin , drug resistance , medicine , biology , virology , antibiotics , gene , escherichia coli , bacteria , genetics
Typhoid fever is endemic in India and other developing countries, causing major public health problems with high morbidity and mortality. The resistance of Salmonella enterica serovar Typhi (S. Typhi) towards commonly prescribed antimicrobials is increasing in developing countries. However, there have been several reports of the therapeutic failure of fluoroquinolones in patients with Salmonella infection. Resistance to quinolones/ fluoroquinolones commonly arises due to target site mutation.