GyrA ser83 and ParC trp106 Mutations in Salmonella enterica Serovar Typhi Isolated from Typhoid Fever Patients in Tertiary Care Hospital | Zendy

Muthu Gopal | Zendy; Sathishkumar Elumalai | Zendy; Arumugam Suresh | Zendy; Vishnuprabu Durairaj Pandian | Zendy; Munirajan Arasambattu Kannan | Zendy; Esthermary Selvam | Zendy; Srivani Seetharaman | Zendy

Open Access

GyrA ser83 and ParC trp106 Mutations in Salmonella enterica Serovar Typhi Isolated from Typhoid Fever Patients in Tertiary Care Hospital

Author(s) -

Muthu Gopal,

Sathishkumar Elumalai,

Arumugam Suresh,

Vishnuprabu Durairaj Pandian,

Munirajan Arasambattu Kannan,

Esthermary Selvam,

Srivani Seetharaman

Publication year - 2016

Publication title -

journal of clinical and diagnostic research

Language(s) - English

Resource type - Journals

eISSN - 2249-782X

pISSN - 0973-709X

DOI - 10.7860/jcdr/2016/17677.8153

Subject(s) - typhoid fever , salmonella typhi , salmonella , microbiology and biotechnology , ciprofloxacin , dna gyrase , salmonella enterica , nalidixic acid , ofloxacin , drug resistance , medicine , biology , virology , antibiotics , gene , escherichia coli , bacteria , genetics

Typhoid fever is endemic in India and other developing countries, causing major public health problems with high morbidity and mortality. The resistance of Salmonella enterica serovar Typhi (S. Typhi) towards commonly prescribed antimicrobials is increasing in developing countries. However, there have been several reports of the therapeutic failure of fluoroquinolones in patients with Salmonella infection. Resistance to quinolones/ fluoroquinolones commonly arises due to target site mutation.

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