Open AccessIdiopathic Pulmonary Fibrosis and Myasthenia Gravis: An Unusual Association
Author(s) -
Bharti Chogtu,
Vasudev Malik Daliparty,
Bharti Chogtu
Publication year - 2016
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2016/17354.7596
Subject(s) - myasthenia gravis , medicine , idiopathic pulmonary fibrosis , interstitial lung disease , pulmonary fibrosis , lung , respiratory failure , neuromuscular junction , fibrosis , neuromuscular disease , weakness , acetylcholine receptor , pathology , disease , surgery , receptor , neuroscience , biology
Idiopathic Pulmonary Fibrosis (IPF) is a chronic fibrosing lung condition with high morbidity and mortality, accounting for about 25% of the cases of interstitial lung diseases. It usually has a progressive course resulting in death due to respiratory failure. Myasthenia Gravis (MG) is an autoimmune neuromuscular disease, caused by antibody mediated activity against acetylcholine receptor at the neuromuscular junction. It is characterized by fluctuating muscle weakness and fatigue. Extensive literature search did not reveal any case report of an association between these two conditions. Here we present a case of a patient with IPF who also developed MG. The diagnosis of IPF was based on High Resolution Computed Tomography (HRCT) of the lung and that of MG was based on clinical criteria and electrophysiological testing. The case was successfully managed.