Open AccessMolecular Characterisation of nfsA Gene in Nitrofurantoin Resistant Uropathogens
Author(s) -
Dhivyalakshmi Shanmugam,
Shamsadh Begum Esak,
N Anbumani
Publication year - 2016
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2016/17280.7957
Subject(s) - nitrofurantoin , klebsiella pneumoniae , microbiology and biotechnology , klebsiella pneumonia , antimicrobial , antibiotics , beta lactamase , escherichia coli , antibiotic resistance , biology , drug resistance , medicine , gene , genetics
Majority of Urinary Tract Infections (UTI's) are lower UTI's which constitute the real burden in the primary care setting and are usually treated empirically. Nitrofurantoin is an underused antimicrobial for empiric therapy for community-acquired and nosocomial lower UTIs. Nitrofurantoin has a wide spectrum of action against Escherichia coli, Klebsiella pneumonia and Enterococci, which are the frequent causes of nosocomial lower UTIs and also against multidrug-resistant gram-negative organisms including extended spectrum beta lactamase (ESBL) producers, Amp-C producers and Carbapenamase producers.