Open AccessBuccal Micronuclei Assay as a Tool For Biomonitoring DNA Damage in Oral Lichen Planus
Author(s) -
Vidyalakshmi Santhanam,
R Madhavan Nirmal,
Veeran Veeravarmal,
A Santhadevy,
R Aravindhan,
Sumathy
Publication year - 2016
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2016/17074.8072
Subject(s) - micronucleus test , buccal administration , oral lichen planus , micronucleus , buccal swab , field cancerization , pathology , dermatology , medicine , biology , cancer , microbiology and biotechnology , dentistry , toxicity
The malignant transformation rate of Oral Lichen Planus (OLP) is between 0% and 5.8%. Oral lesions of lichen planus clinically presents itself multifocally, simulating the process of field cancerization in high risk malignancies. The Buccal MicroNucleus Cytome Assay (BMN Assay) provides a platform to identify the high risk individuals by evaluating the markers of nuclear damage at an earliest micro invasive phase.