Buccal Micronuclei Assay as a Tool For Biomonitoring DNA Damage in Oral Lichen Planus | Zendy

Vidyalakshmi Santhanam | Zendy; R Madhavan Nirmal | Zendy; Veeran Veeravarmal | Zendy; A Santhadevy | Zendy; R Aravindhan | Zendy; Sumathy | Zendy

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Buccal Micronuclei Assay as a Tool For Biomonitoring DNA Damage in Oral Lichen Planus

Author(s) -

Vidyalakshmi Santhanam,

R Madhavan Nirmal,

Veeran Veeravarmal,

A Santhadevy,

R Aravindhan,

Sumathy

Publication year - 2016

Publication title -

journal of clinical and diagnostic research

Language(s) - English

Resource type - Journals

eISSN - 2249-782X

pISSN - 0973-709X

DOI - 10.7860/jcdr/2016/17074.8072

Subject(s) - micronucleus test , buccal administration , oral lichen planus , micronucleus , buccal swab , field cancerization , pathology , dermatology , medicine , biology , cancer , microbiology and biotechnology , dentistry , toxicity

The malignant transformation rate of Oral Lichen Planus (OLP) is between 0% and 5.8%. Oral lesions of lichen planus clinically presents itself multifocally, simulating the process of field cancerization in high risk malignancies. The Buccal MicroNucleus Cytome Assay (BMN Assay) provides a platform to identify the high risk individuals by evaluating the markers of nuclear damage at an earliest micro invasive phase.

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