Open AccessBaroreflex Dysfunction in Prader Willi Syndrome
Author(s) -
Manpreet Kaur,
Shival Srivastav,
Ashok Kumar Jaryal,
Kishore Kumar Deepak
Publication year - 2016
Publication title -
journal of clinical and diagnostic research
Language(s) - Uncategorized
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2016/17064.7410
Subject(s) - baroreflex , medicine , blood pressure , cardiology , orthostatic vital signs , autonomic function , heart rate , autonomic nervous system , valsalva maneuver , tachycardia , dysautonomia , heart rate variability , disease
Prader-Willi syndrome is a classical hypothalamic insufficiency disorder. This syndrome is often associated with cardiovascular morbidity and mortality - which could probably be attributed to autonomic dysfunction. A 21-year-old Prader Willi syndrome patient was referred for cardiovascular and autonomic function assessment. We performed a battery of tests assessing vascular structure (carotid intima thickness), vascular function (arterial stiffness indices), baroreflex sensitivity (overall integrator of short term regulation of blood pressure), blood pressure variability and autonomic tone (heart rate variability) along with autonomic reactivity tests. We observed impaired baroreflex sensitivity along with orthostatic tachycardia with normal vascular function tests. Prader- Willi syndrome patient have baroreflex dysfunction with probable afferent and/ central autonomic neural defects.