Open AccessHepatosplenic T Cell Lymphoma in an Immunocompetent Female Diagnosed using Flow Cytometry: A Rare Clinical Entity
Author(s) -
Pranav Dorwal,
Ritesh Sachdev,
Amit Pande,
Dharmendra Jain,
Bhawna Jha,
Vimarsh Raina
Publication year - 2016
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2016/16943.8355
Subject(s) - hepatosplenomegaly , cd5 , pancytopenia , pathology , cd3 , lymphoma , medicine , cd8 , bone marrow , pallor , malignancy , t cell lymphoma , t cell , immunology , antigen , immune system , disease
Hepatosplenic T-cell lymphoma is a rare haematopoietic malignancy that comprises less than 1% of Non-Hodgkin lymphomas. We are reporting a case of a 26-year-old female, who presented with pallor, weight loss, jaundice, pancytopenia and hepatosplenomegaly. The bone marrow examination showed infiltration by lymphoid cells. These cells on flow cytometric evaluation showed the phenotype of hepatosplenic T cell lymphoma. The cells were positive for CD3, CD8, CD56 and TCR γδ and negative for CD5, CD4, CD8, CD16, CD57, TCRαβ along with B cell markers. This case is reported for being a rare clinical entity and its presence in an immunocompetent female making it rarer.