Open AccessSero-Negative Systemic Sclerosis: A Rare Presentation
Author(s) -
Rakesh Chander,
Sehijpal Singh,
Siddhesh Arun Kalantri,
Shiv Charan,
Abhishek Gupta
Publication year - 2016
Publication title -
journal of clinical and diagnostic research
Language(s) - Uncategorized
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2016/16780.7973
Subject(s) - medicine , progressive systemic sclerosis , scleroderma (fungus) , presentation (obstetrics) , disease , serology , rare disease , systemic disease , dermatology , pathology , multisystem disease , antibody , immunology , surgery , inoculation
Systemic Sclerosis is a multisystem disease associated with progressive fibrosis of skin and internal organs. It is diagnosed by presence of characteristic clinical findings and is supported by specific serologic abnormalities. ANA is positive in case of systemic sclerosis in 90 percent of cases. We report a rare case of this rare disease where patient was ANA, Antitopoisomerase I (anti-Scl-70), Anticenteromere antibody negative.