Open AccessA Randomised Controlled Trial Comparing the Efficacy and Side-Effects of Intravaginal Ring (Nuvaring ® ) With Combined Oral Hormonal Preparation in Dysfunctional Uterine Bleeding
Author(s) -
Sandhya Jain,
Neelam Vaid,
Yam Narang,
Amita Suneja,
Kiran Guleria
Publication year - 2016
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2016/16545.7516
Subject(s) - medicine , levonorgestrel , ethinylestradiol , desogestrel , breakthrough bleeding , pill , population , menstrual cycle , gynecology , family planning , hormone , pharmacology , environmental health , research methodology
Combined Oral Contraceptive (COC) pills are being used in patients of abnormal uterine bleeding, especially adolescents and reproductive age women considering their need for contraception. It decreases the blood loss due to haemostatic effect of estrogen and also regularizes the cycle. Intravaginal route has been found to be effective and acceptable; Gastrointestinal absorption and hepatic first-pass metabolism is avoided and steady, uniform blood concentration is achieved. Bioavailability of estrogen and progestogen through oral and vaginal route are same. The convenience of once-a-month administration is another major advantage.