Open AccessAdipokines and their Relation to Endothelial Dysfunction in Patients with Chronic Kidney Disease
Author(s) -
Madhusudan Ambarkar,
Srinivasarao V L N Pemmaraju,
Sivakrishna Gouroju,
Suchitra M. Manohar,
Aparna R. Bitla,
Naresh Yajamanam,
Sivakumar Vishnubhotla
Publication year - 2016
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2016/15867.7060
Subject(s) - medicine , adipokine , kidney disease , renal function , univariate analysis , gastroenterology , endothelial dysfunction , adiponectin , inflammation , interleukin 6 , leptin , endocrinology , multivariate analysis , obesity , insulin resistance
Chronic Kidney Disease (CKD) patients are at high risk of cardiovascular diseases (CVDs). Reduced nitric oxide (NO) bioavailability is a key element in connecting kidney disease to endothelial dysfunction (ED) and cardiovascular (CV) complications. Further, inflammation is implicated in ED in CKD. Besides these, adipose tissue factors were thought to have a role in inflammation and ED in CKD.