Open AccessCan MMP-9 be a Prognosticator Marker for Oral Squamous Cell Carcinoma?
Author(s) -
Betina Chandolia,
Shiva Kumar Basu,
Manish Kumar
Publication year - 2016
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2016/14128.7034
Subject(s) - pathology , epithelial dysplasia , haematoxylin , medicine , metastasis , carcinoma , immunohistochemistry , epithelium , cancer , oral mucosa , dysplasia
Invasion and metastasis of malignant tumours severely endanger the life of cancer patients. Squamous cell carcinoma is one of the commonly found malignancies in the oral cavity and its survival rate has not improved from past few decades. Since an important risk factor for oral squamous cell carcinoma is the presence of epithelial dysplasia, it is necessary to check the presence of a prognosticator marker in both of them. As matrix metalloproteinase's (MMP's) are involved in degradation of type IV collagen, which are one of the important components of extracellular matrix components which play a relevant role in several steps of tumour progression such as invasion and metastasis. We have studied MMP-9 expression to evaluate its prognostic potential in oral cancers as well as oral epithelial dysplasia along with tissues of normal oral epithelium.