The Study of MIB -1 LI and CD 34 As A Marker of Proliferative Activity and Angiogenesis in Different Grades of Meningioma | Zendy

Harishkumar Bohra | Zendy; Khushi Ram Rathi | Zendy; Sharmila Dudani | Zendy; Ashish Bohra | Zendy; Sumit Kumar Vishwakarma | Zendy; Kavita Sahai | Zendy

Open Access

The Study of MIB -1 LI and CD 34 As A Marker of Proliferative Activity and Angiogenesis in Different Grades of Meningioma

Author(s) -

Harishkumar Bohra,

Khushi Ram Rathi,

Sharmila Dudani,

Ashish Bohra,

Sumit Kumar Vishwakarma,

Kavita Sahai

Publication year - 2016

Publication title -

journal of clinical and diagnostic research

Language(s) - English

Resource type - Journals

eISSN - 2249-782X

pISSN - 0973-709X

DOI - 10.7860/jcdr/2016/12690.8328

Subject(s) - grading (engineering) , medicine , haematoxylin , meningioma , angiogenesis , pathology , immunohistochemistry , cd34 , vascularity , biopsy , biology , ecology , genetics , stem cell

Meningiomas comprise 24-30% of all tumours occurring in the central nervous system. Conventional morphologic critera as studied in routine Haematoxylin and Eosin stained sections (H & E) may not be accurate in grading and assessing prognosis in small stereotactic biopsy specimens. Thus, arises the need for objective methods for assessing tumour biology. Angiogenesis is a key event in the spread of tumours and denotes a poor prognosis. Intratumoural Microvessel Density (MVD) helps in quantification of angiogenesis.

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