Open AccessThe Study of MIB -1 LI and CD 34 As A Marker of Proliferative Activity and Angiogenesis in Different Grades of Meningioma
Author(s) -
Harishkumar Bohra,
KR Rathi,
Sharmila Dudani,
Ashish Bohra,
Sumit Kumar Vishwakarma,
Kavita Sahai
Publication year - 2016
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2016/12690.8328
Subject(s) - grading (engineering) , haematoxylin , medicine , meningioma , angiogenesis , pathology , immunohistochemistry , cd34 , vascularity , biopsy , biology , ecology , genetics , stem cell
Meningiomas comprise 24-30% of all tumours occurring in the central nervous system. Conventional morphologic critera as studied in routine Haematoxylin and Eosin stained sections (H & E) may not be accurate in grading and assessing prognosis in small stereotactic biopsy specimens. Thus, arises the need for objective methods for assessing tumour biology. Angiogenesis is a key event in the spread of tumours and denotes a poor prognosis. Intratumoural Microvessel Density (MVD) helps in quantification of angiogenesis.