Open AccessEvaluation of Anti Cancer Effects of D PP -4 Inhibitors in Colon Cancer- An Invitro Study
Author(s) -
C A Amritha,
Punnagai Kumaravelu,
Darling Chellathai
Publication year - 2015
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2015/16015.6979
Subject(s) - vildagliptin , mtt assay , sitagliptin , chemistry , pharmacology , ic50 , viability assay , in vitro , cell culture , in vivo , biochemistry , medicine , metformin , endocrinology , biology , diabetes mellitus , microbiology and biotechnology , genetics
Among the oral anti-diabetic drugs, Dipeptidyl peptidase - 4(DPP-4) inhibitor is an emerging class of drugs. Inhibitors of DPP-4 enzyme like Sitagliptin and Vildagliptin have shown Anti-oxidant properties in many studies, both invivo and invitro. It has also been characterized as an apoptotic agent on pancreatic cancer cells. In the following study, Anticancer effect of DPP 4 inhibitors on colon cell lines (HT-29) using MTT assay- {3 -4, 5-dimethyl (thiazol - 2 -yl) -3, 5- dimethyl tetrazolium bromide} assay was elucidated.