Open AccessValproate Induced Hyperammonemic Delirium
Author(s) -
Anupama Muraleedharan,
Dhanya Sasidharan Palappallil,
Reneega Gangadhar,
Soumitra Das
Publication year - 2015
Publication title -
journal of clinical and diagnostic research
Language(s) - Uncategorized
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2015/15562.6883
Subject(s) - delirium , mania , medicine , hyperammonemia , adverse effect , psychosis , psychiatry , liver function , pediatrics , bipolar disorder , anesthesia , lithium (medication)
Sodium valproate induced hyperammonaemic delirium with normal liver function tests is a relatively uncommon adverse effect. It may be mistaken for psychosis or worsening of mania leading to wrong diagnosis and improper management. Plasma ammonia levels should be monitored in all patients developing altered mental status after receiving valproate therapy. This is a case series of hyperammonaemic delirium due to valproate reported to the Department of Pharmacology from Department of Psychiatry over a period of one year.