Open AccessBetacellulin in Chronic Periodontitis Patients With and Without Type 2 Diabetes Mellitus: An Immunohistochemical Study
Author(s) -
Gauri Mahesh Ugale,
Nagaraj B Kalburgi,
Shivaprasad Bilichodmath,
Shivaraj Warad,
Mahesh Ugale,
Arati C Koregol,
Shobha C Bijjargi
Publication year - 2015
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2015/15275.6725
Subject(s) - epidermal growth factor , chronic periodontitis , amphiregulin , medicine , periodontitis , epiregulin , transforming growth factor , immune system , immunohistochemistry , growth factor , immunology , receptor
The host immune response to bacterial dental plaque determines periodontal disease susceptibility by increasing the secretion of inflammatory cytokines. The Epidermal Growth Factor family cytokines stimulate proliferation and keratinization of cells in dermis and oral epithelium. Epidermal Growth Factor family consists of Amphiregulin, Betacellulin, Epiregulin, Epigen, Heparin binding Epidermal Growth Factor like growth factor and transforming Growth Factor-alpha.