Open AccessMetronidazole-Induced Bullous Pemphigoid: A Case Report
Author(s) -
Saibal Moitra,
Sukanta Sen,
Indranil Banerjee,
Ayan Sikder,
Prasanta Kumar Das
Publication year - 2015
Publication title -
journal of clinical and diagnostic research
Language(s) - Uncategorized
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2015/14669.6972
Subject(s) - medicine , bullous pemphigoid , metronidazole , dermatology , levofloxacin , pemphigoid , pharmacovigilance , drug , antibiotics , pharmacology , immunology , antibody , microbiology and biotechnology , biology
Bullous pemphigoid is an autoimmune cutaneous blistering disorder, the exact pathogenesis of which is still not fully elucidated. Drug-induced bullous pemphigoid eruptions are rare but have been reported earlier with the use of frusemide, psoralens, ibuprofen, galantamine hydrobromide, ACE inhibitors like captopril, spironolactone, penicillin, ampicillin, levofloxacin, penicillamine. We hereby report a case of metronidazole induced bullous pemphigoid (BP) in a 52-year-old male patient suffering from liver abscess following 4 days of drug administration. The skin biopsy findings obtained from the patient were consistent with the diagnosis of bullous pemphigoid (BP). Metronidazole was discontinued and symptomatic treatment was offered to the patient. Following withdrawal of metronidazole, the bullae subsided in the next 7-10 days without any significant residual scarring. The causality assessment performed as per the Naranjo algorithm revealed the case to be probable (Naranjo score 7).