Open AccessSerum Adenosine Deaminase as Inflammatory Marker in Rheumatoid Arthritis
Author(s) -
Kiranmayi S Vinapamula,
Srinivasarao V L N Pemmaraju,
Siddartha Kumar Bhattaram,
Aparna R. Bitla,
Suchitra M. Manohar
Publication year - 2015
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2015/14296.6483
Subject(s) - adenosine deaminase , rheumatoid arthritis , medicine , receiver operating characteristic , c reactive protein , inflammation , gastroenterology , arthritis , immunology , adenosine
Rheumatoid arthritis (RA) is a prototypical inflammatory joint disease. The degree of inflammation is reflected in the extent of joint damage, which further has influence on the quality of life of patients with RA, including risk of atherosclerosis. Hence, besides clinical indices, estimation of degree of inflammation using biochemical markers helps in effecting optimum treatment strategies. C-reactive protein (CRP) is established as an inflammatory marker in patients with RA. Adenosine deaminase (ADA), an enzyme of purine metabolism is considered as a marker of cell mediated immunity and has also been suggested as a marker of inflammatory process in RA. The present study attempts to study the efficacy of serum ADA activity as an inflammatory marker in RA.