Open AccessNeuroprotective Effect of Lercanidipine- A Novel Calcium Channel Blocker in Albino Mice
Author(s) -
Nitya Selvaraj,
Mangaiarkkarasi Adhimoolam,
Deepa Kameswari Perumal,
Meher Ali Rajamohammed
Publication year - 2015
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2015/14085.6801
Subject(s) - lercanidipine , anticonvulsant , dihydropyridine , pharmacology , diazepam , phenytoin , muscle relaxant , calcium channel , medicine , epilepsy , calcium , chemistry , anesthesia , blood pressure , psychiatry
The available conventional antiepileptics do not afford cure or prophylactic treatment and henceforth there is always a quest to explore new targets for management of convulsions. In this perspective, dihydropyridine calcium channel blockers have been investigated in various animal models of epilepsy. Lercanidipine, a newer dihydropyridine calcium antagonist, is a potential candidate with its favourable lipid profile and longer duration of action.