Open AccessPrevalence of M LSB Resistance and Observation of erm A & erm C Genes At A Tertiary Care Hospital
Author(s) -
A. M. A. Abbas,
Preeti Srivastava,
PS Nirwan
Publication year - 2015
Publication title -
journal of clinical and diagnostic research
Language(s) - English
Resource type - Journals
eISSN - 2249-782X
pISSN - 0973-709X
DOI - 10.7860/jcdr/2015/13584.6112
Subject(s) - clindamycin , linezolid , staphylococcus aureus , microbiology and biotechnology , vancomycin , methicillin resistant staphylococcus aureus , drug resistance , antibiotics , erythromycin , medicine , biology , bacteria , genetics
The increasing resistance to macrolide, lincosamide, streptogramin B (MLSB) agents among Staphylococcus aureus is becoming a challenge to microbiologist. Clindamycin has been a useful drug for treatment of infection caused by the staphylococcus aureus, but change in clindamycin sensitivity pattern due to various mechanisms is leading to therapeutic failure. One of the important mechanisms is mediation of resistance by erm genes. Staphylococcus strains which have erm genes show inducible clindamycin resistance that cannot be determined by routine disk diffusion test resulting in treatment failure.